The discovery and development of new pharmaceutical drugs is a challenging feat. Ensuring the safety and efficacy profiles of new products for the consumer market requires a significant investment of time, money, and research.
As the industry standard, utilizing 14C radiolabeled API helps yield valuable quantitative information during this process. Why is carbon-14 the first choice for modern radiolabeling? Labeling your active pharmaceutical ingredient with carbon-14 technology solutions offers numerous advantages for clinical study progression.
Radiolabeling: The Radioactive Elements of Choice
The science behind radioactive materials can profoundly impact human life today. In the pharmaceutical industry, the labeling methods used for drug products currently in development help provide unique solutions to innovation challenges. When using radiolabeling technology, the labeling method of choice can influence the retention and distribution of the radiolabeled compound.
Researchers must use radioactive elements of choice to examine and evaluate a drug’s toxicological profile. Drugs synthesized by custom carbon-14 radiolabels use the first radioactive element of choice and can easily trace distribution in the human body for safety and efficiency purposes.
Carbon-14: Radiochemical Stability
Labeling an active pharmaceutical ingredient with carbon-14 is the best method because of its innate properties. This radioactive form of carbon—the chemical backbone of all organic molecules—is the mainstay of radiolabeled pharmaceutical drugs due to its metabolic stability.
With a half-life of around 5,700 years and easy detection at low levels, researchers can obtain reliable quantitative data with carbon-14 compared to other radioactive isotopes. Carbon-14 is a fundamental tool for speeding up clinical study processes and enabling precise monitoring in analytical work.
Contract Isotope Labeling Services
The isotopic labeling of active pharmaceutical ingredients poses a variety of challenges due to the complexity of syntheses and advancements in technology. For this reason, the knowledge of experienced groups is essential for appropriately labeling these materials in a precise and cost-effective manner.
Moravek is a contract organization that provides a custom isotope labeling service for carbon-14 radiolabeled compounds. Our state-of-the-art facilities and skilled team of chemists support a range of critical research projects and clinical studies for our clients. Discover more about the quality, expert knowledge, and advanced technology Moravek can offer.